This protocol addresses juvenile xanthogranuloma presenting with ocular involvement — a distinct and clinically significant manifestation that requires targeted management.
Ocular JXG is nearly always unilateral and generally affects the iris, although the orbit, optic nerve, choroid, and conjunctiva may also be affected.
Management of ocular JXG involves a structured therapeutic strategy; in select cases, radiation therapy forms part of the approach. The full protocol covers the complete sequence of interventions, criteria for escalation, and management of associated complications.
DOI: 10.1016/j.adengl.2020.10.007
Ocular JXG is nearly always unilateral and generally affects the iris, although the orbit, optic nerve, choroid, and conjunctiva may also be affected.
Topical and intralesional corticoids are usually used to treat ocular JXG, while systemic corticosteroids or surgery may be needed to treat rapidly progressive lesions or complications, such as glaucoma or hyphema; there have also been isolated reports of good response to radiation therapy and chemotherapy.
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