What is the treatment of colorectal polyps in Juvenile polyposis syndrome?

Clinical scenario

Juvenile polyposis syndrome (JPS) is characterised by multiple colorectal juvenile polyps that carry a risk of significant complications, including rectal bleeding and anaemia. Management focuses on systematic endoscopic surveillance and polyp removal to prevent these outcomes.

Treatment approach

The primary intervention is endoscopic colonoscopic polypectomy. Retrieved polyps are submitted for histological assessment. The complete protocol — including the criteria for which polyps are prioritised, the surveillance schedule, and how endpoints are confirmed — is set out in the structured regimen.

Clinical goals

Avoidance of rectal bleeding and anaemia
Resection of all significant colorectal polyps

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1097/MPG.0000000000002246

Once polyps (>10 mm) are detected they should be removed and colonoscopy repeated annually until polyps >10 mm have been resected, then repeated every 1 to 5 years.
When polyps are identified they should be removed to avoid bleeding and anaemia.
Ideally, colonoscopy should aim to remove all polyps >10 mm, and repeated annually until polyps of this size have been resected.

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