Treatment of Iron-Deficiency Anemia in Portal Hypertensive Gastropathy

Iron-deficiency anemia arising in the context of portal hypertensive gastropathy (PHG) requires an approach that addresses both the iron deficit itself and the underlying portal hypertension driving ongoing blood loss.

This protocol applies to patients with portal hypertensive gastropathy who develop iron-deficiency anemia. Portal hypertensive gastropathy is a recognised source of chronic blood loss, and the coexistence of these two conditions shapes both the diagnostic and therapeutic approach.

Initial management focuses on oral iron supplementation to replenish iron stores — and importantly, no malabsorptive defect is known in PHG, so oral therapy is generally sufficient. Beyond iron repletion, consideration may be given to addressing the portal hypertension itself under specific circumstances. The complete protocol — including the full sequencing, criteria for escalation, and further management steps — is detailed in the structured regimen.