When infective endocarditis presents with persistently negative blood cultures, Bartonella spp. is an important cause to consider. Standard culture techniques typically fail to isolate this organism, making serological testing a key diagnostic step.
Blood culture-negative infective endocarditis in which Bartonella spp. has been identified or is the suspected pathogen — requiring a targeted antibiotic approach distinct from culture-positive endocarditis management.
The regimen involves a combination of doxycycline and gentamicin. Specific dosing, duration, and route of administration for each agent are detailed in the full protocol.