What Is the Treatment for Impotence of Organic Origin?

Impotence of organic origin — erectile dysfunction (ED) arising from a physical cause — is defined as the consistent or recurrent inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance. First-line management follows a structured, evidence-based protocol combining behavioural and pharmacological interventions.

Clinical goal Penile erection sufficient for satisfactory sexual performance

Treatment approach (partial overview)

First-line management incorporates lifestyle modifications — including changes in diet and increased physical activity — alongside an established class of oral pharmacotherapy, with the specific agent and dosing approach selected and titrated to the individual patient.

Agent selection, dose titration guidance, and the complete structured regimen are available in the full protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.juro.2018.05.004

Erectile dysfunction (ED) can be conceptualized as an impairment in the arousal phase of sexual response and is defined as the consistent or recurrent inability to attain and/or maintain penile erection sufficient for sexual satisfaction, including satisfactory sexual performance.

Clinicians should counsel men with ED who have comorbidities known to negatively affect erectile function that lifestyle modifications, including changes in diet and increased physical activity, improve overall health and may improve erectile function.

Men with ED should be informed regarding the treatment option of an FDA-approved oral phosphodiesterase type 5 inhibitor (PDE5i), including discussion of benefits and risks/burdens, unless contraindicated.

For men who are prescribed PDE5i, the dose should be titrated to provide optimal efficacy.

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