This first-line protocol addresses adult males with hypopituitarism who have confirmed central hypogonadism and low serum testosterone levels, with no contraindications to treatment.
Central hypogonadism in males manifests with low serum testosterone levels and features of testosterone deficiency and/or impaired spermatogenesis. Confirmed low serum testosterone in this setting is the key qualifying finding driving the management decision.
The recommended strategy involves testosterone replacement therapy. Specific formulation selection, monitoring intervals, and the complete decision algorithm are available in the full protocol.
DOI: 10.1210/jc.2016-2118
Central hypogonadism in males manifests with low serum T levels and features of T deficiency and/or impaired spermatogenesis.
We suggest T replacement for adult males with central hypogonadism and no contraindications in order to prevent anemia related to T deficiency; reduce fat mass; and improve BMD, libido, sexual function, energy levels, sense of well-being, and muscle mass and strength.
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