Hyperemesis Gravidarum Not Responding to Ondansetron: Next-Line Management

This protocol covers the next management step for hyperemesis gravidarum when standard antiemetic therapy has been tried and the primary clinical goal — resolution of nausea and vomiting — has not been reached.

Previous Treatment — Target Not Achieved

Antiemetic therapy with Ondansetron — and, where reflux was a contributing factor, Famotidine or Omeprazole — did not achieve resolution of nausea and vomiting. Escalation to the next line of management is indicated.

This Protocol

Once antiemetic medications and IV hydration have not been sufficient, steroid-based therapy forms the basis of the next approach — with further options available in selected cases. The complete agent choices, sequencing, and clinical decision points are in the full protocol.

Clinical Target

Resolution of nausea and vomiting.

Instant Access to Structured Evidence-Based Regimens

References

Steroids should only be used if antiemetic medications and IV hydration have failed.

View source ↗