Hyperemesis Gravidarum: Next Step When Metoclopramide or Prochlorperazine Has Not Worked
This protocol applies to hyperemesis gravidarum where a course of a standard first-line antiemetic — metoclopramide or prochlorperazine — has been completed without achieving the intended clinical goal.
Previous treatment line — failure condition
Treatment with metoclopramide or prochlorperazine did not achieve the target outcome: resolution of nausea and vomiting. This protocol is the next clinical step after that failure.
Treatment approach — partial overview
This line introduces an alternative antiemetic agent indicated when other antiemetics have been ineffective or poorly tolerated. Where reflux is identified as a contributing factor, addressing it may provide additional symptom relief. Full agent selection, dosing, route, and sequencing are detailed in the complete protocol.
Target outcome
Resolution of nausea and vomiting.
References
- It should be used if other antiemetics are ineffective or poorly tolerated.
- Treatment of reflux often improves symptoms of nausea and vomiting.
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