Treatment of Huntington's Disease with Rigidity and Increased Muscle Tone

This protocol addresses Huntington's disease in patients presenting with rigidity — an increase in muscle tone that leads to resistance to passive movement, joint stiffness, and limited range of motion. These features can be distressing and functionally significant, and call for a treatment approach distinct from the more common hyperkinetic presentation.

Management in this setting involves Levodopa alongside a physical rehabilitation strategy — the specific dosing approach, sequencing, and rehabilitation goals are detailed in the full protocol.

The complete regimen — including selection criteria, titration strategy, and clinical decision points — is available below.