गंभीर बीटा-लैक्टम एलर्जी के बिना स्ट्रेप्टोकोकल मेनिनजाइटिस का उपचार

References

1. The committee agreed that ceftriaxone should be given as first-line treatment for Streptococcus pneumoniae meningitis, unless contraindicated in which case cefotaxime can be considered.
2. The committee agreed that a cephalosporin should still be considered if the nature of the allergic reaction they get is not severe, in accordance with the first line treatment recommended above.
3. The committee recommended that people with meningitis caused by Streptococcus pneumoniae should be treated for 10 days with ceftriaxone (or cefotaxime if ceftriaxone contraindicated).
4. The committee were aware that insufficient dose can increase the risk of treatment failure and antibiotic resistance; therefore, they agreed to use the maximum dose recommended by the BNF or BNFC or follow local antimicrobial guidance.
5. The committee highlighted the practical and resource-use advantages associated with ceftriaxone because the long half-life means that it may be given only once a day.
6. The committee considered that it would be cost-effective to recommend stopping intravenous ceftriaxone for Streptococcus pneumoniae meningitis after 10 days providing the person had clinically recovered.