सिकल सेल क्राइसिस का उपचार: आपातकालीन सेटिंग में तीव्र दर्द प्रबंधन

DOI: 10.1182/bloodadvances.2020001851

For adults and children with SCD presenting to an acute care setting with acute pain related to SCD, the ASH guideline panel recommends rapid (within 1 hour of ED arrival) assessment and administration of analgesia with frequent reassessments (every 30 to 60 minutes) to optimize pain control (strong recommendation based on low certainty in the evidence about effects).

For adults and children with SCD presenting to an acute care setting with acute pain related to SCD for whom opioid therapy is indicated, the ASH guideline panel suggests tailored opioid dosing based on consideration of baseline opioid therapy and prior effective therapy (for adults: conditional recommendation based on moderate certainty in the evidence about effects; for children: conditional recommendation based on low certainty in the evidence about effects).

For adults and children with acute pain related to SCD, the ASH guideline panel suggests a short course (5 to 7 days) of NSAIDs in addition to opioids for acute pain management (conditional recommendation based on very low certainty in the evidence about effects).

For adults and children who seek treatment of acute pain, the ASH guideline panel suggests massage, yoga, TENS, VR, and guided AV relaxation in addition to standard pharmacological management (conditional recommendation based on very low certainty in the evidence about effects).

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