गर्भावस्था में द्वितीयक सिफलिस का उपचार

References

• Patients should be treated appropriately for the stage of disease, according to the BASHH UK national guidelines on the management of syphilis 2023.
• In the absence of allergy to penicillin, standard benzathine penicillin G treatment should be given.
• For these reasons, when treatment for early syphilis is initiated in the third trimester, a second dose of benzathine penicillin G is recommended 1 week after the first, with careful assessment of the neonate at birth.
• The non-penicillin alternative is ceftriaxone, for which limited data are available.
• If a patient is allergic to penicillin but not ceftriaxone, ceftriaxone can be used or penicillin desensitisation and immediate penicillin treatment can be considered.
• In the case of soya or peanut allergy, refer for allergy testing or treat with procaine penicillin or ceftriaxone.
• It may take several months to observe a 4-fold drop in RPR titre and in many pregnancies delivery will occur beforehand.