फैंकोनी सिंड्रोम में प्रॉक्सिमल रेनल ट्यूबुलर एसिडोसिस का उपचार

References

1. Proximal RTA may occur as an isolated defect in HCO3– reabsorption, but more typically occurs in association with Fanconi syndrome, characterized by a widespread proximal tubular dysfunction resulting in the loss of phosphate, glucose, uric acid, amino acids, and low molecular weight proteins, as well as HCO3–.
2. In contrast, treatment of proximal RTA is often challenging and patients require larger quantities of alkali therapy, which are usually administered as a K+ salt (e.g., K-citrate) to avoid worsening hypokalemia.
3. In addition to alkali therapy, patients with Fanconi syndrome are treated with fluid and electrolyte replacement to prevent volume depletion, as well as supplementation with vitamin D and phosphate to prevent bone disease.

DOI: 10.6084/m9.figshare.13286027