गर्भावस्था में प्राथमिक सिफलिस का उपचार

References

1. All pregnant women and people should have serological screening for syphilis as part of their first antenatal assessment.
2. In the absence of allergy to penicillin, standard benzathine penicillin G treatment should be given.
3. Limited evidence suggests that a second dose of benzathine penicillin G 1 week after the first may be beneficial for fetal treatment in pregnant women or people with early syphilis, and in pregnancies with sonographic signs of fetal or placental syphilis as this indicates a greater risk of fetal treatment failure.
4. For these reasons, when treatment for early syphilis is initiated in the third trimester, a second dose of benzathine penicillin G is recommended 1 week after the first, with careful assessment of the neonate at birth.
5. It may take several months to observe a 4-fold drop in RPR titre and in many pregnancies delivery will occur beforehand.