मध्यम से गंभीर पेम्फिगस जब प्रथम-पंक्ति चिकित्सा ने रोग नियंत्रण प्राप्त नहीं किया है

References

DOI: 10.1111/jdv.16752

• And/or skin lesions >5% BSA.
• Moderate pemphigus PDAI score > 15 and ≤ 45.
• Severe pemphigus: PDAI score > 45.
• Initially treated with rituximab and prednisone → increase the prednisone dose up to 1.5 mg/kg/d or → intravenous corticosteroids pulses
• Initially treated with systemic corticosteroids (1.0 mg/kg/d) alone → increase the prednisone dose to 1.5 mg/kg/d PLUS rituximab (2x1g) or → add immunosuppressant (azathioprine 1 to 2.5 mg/kg/d or mycophenolate mofetil 2g/d or mycophenolate sodium 1440 mg/d)
• Initially treated with prednisone (1.5 mg/kg/d) alone → add rituximab (2x1g) or → add immunosuppressant (azathioprine 1 to 2.5 mg/kg/d or mycophenolate mofetil 2g/d or mycophenolate sodium 1440 mg/d)
• Disease control