यह प्रोटोकॉल अनरिसेक्टेबल स्थानीय रूप से उन्नत या मेटास्टेटिक मायक्सोफाइब्रोसार्कोमा वाले उन रोगियों पर लागू होता है — एक अवस्था जो अत्यंत खराब पूर्वानुमान से जुड़ी है — जो पहले से ही पर्याप्त प्रतिक्रिया प्राप्त किए बिना प्रथम-पंक्ति एंथ्रासाइक्लिन-आधारित प्रणालीगत चिकित्सा प्राप्त कर चुके हैं।
एंथ्रासाइक्लिन के साथ या बिना आइफोस्फेमाइड के साथ प्रथम-पंक्ति उपचार ने इमेजिंग पर आंशिक ट्यूमर प्रतिक्रिया के आवश्यक लक्ष्य को पूरा नहीं किया।
अपर्याप्त रेडियोलॉजिकल प्रतिक्रिया → अगली पंक्ति पर आगे बढ़ेंDOI: 10.3390/diagnostics13193022
The development of unresectable locally advanced or metastatic MFS is assocaited with a very poor prognosis.
Gemcitabine can be used as a monotherapy or in combination with docetaxel or dacarbazine in pretreated STS patients.
Although the exact role of gemcitabine remains unclear, gemcitabine-based therapy can be an effective option for metastatic MFS patients.
Trabectedin can be administered effectively and safely to patients with advanced STS at second- or later-line setting.
Japan is the only country where eribulin is approved for all types of STS, including non-L-sarcomas such as MFS and UPS.
Pazopanib is an oral multitargeted tyrosine kinase inhibitor (TKI) with anti-angiogenic and anti-tumorigenic properties and it has been approved in multiple countries as a second- or later-line treatment for patients with advanced non-adipocytic STS.
In a single-arm open-label multicenter phase 2 trial (SARC028), pembrolizumab (anti-PD-1 antibody) provided an objective response rate (ORR) of 18% in the STS cohort.
In a randomized open-label non-comparative multicenter phase 2 trial (Alliance A091401), 85 patients with metastatic sarcoma received either nivolumab alone or nivolumab in combination with ipilimumab (anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody).
A radiological PR or complete response (CR) was observed in four (57%) of the seven patients.
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