23 सप्ताह की गर्भावस्था में मातृ बुखार और दो या अधिक नैदानिक संकेतों के साथ नैदानिक कोरिओएमनियोनाइटिस का उपचार

• Clinical chorioamnionitis has been traditionally diagnosed by the presence of maternal fever (temperature ≥37.8°C or ≥38.0°C) plus two or more of the five following clinical signs: maternal tachycardia (heart rate >100 beats/min), fetal tachycardia (heart rate >160 beats/min), uterine tenderness, purulent or foul-smelling amniotic fluid or vaginal discharge, and maternal leukocytosis (white blood cell count >15,000/mm³).
• In summary, although there is insufficient data to demonstrate the most appropriate antimicrobial regimen for the treatment of this obstetric condition, current available evidence indicates that women with clinical chorioamnionitis, mainly those with a gestational age ≥34 weeks and in labor, can be treated with ampicillin 2 g IV every 6 hours combined with gentamicin 5 mg/kg every 24 hours or 1.5 mg/kg every 8 hours, or ampicillin/sulbactam 3 g IV every 6 hours.
• Thus, it appears reasonable to administer ACS to women with clinical chorioamnionitis between 24 0/7 and 33 6/7 weeks of gestation and to consider its administration to those with a gestational age between 23 0/7 and 23 6/7 weeks.
• Recently, it was reported that two patients with intrapartum fever and fetal tachycardia had a reduction of maternal temperature and resolution of fetal tachycardia 20 minutes after administration of acetaminophen 1 g IV.

DOI: 10.1016/j.ajog.2020.09.044