गर्भावस्था में बुरुली अल्सर का उपचार

References

• Rifampicin at 10 mg/kg body weight by mouth daily for 8 weeks and streptomycin at 15 mg/kg body weight by intramuscular injection daily for 8 weeks (contraindicated in pregnancy).
• A pregnant patient in Benin was successfully treated with a combination of rifampicin and clarithromycin (34).
• The recommendation, based on expert opinion, is therefore: rifampicin at 10 mg/kg body weight by mouth daily for 8 weeks and clarithromycin at 7.5 mg/kg body weight by mouth twice daily for 8 weeks.
• The extended-release formulation of clarithromycin may be used at 15 mg/kg body weight once daily, although it has yet to be tested.
• This guidance was based on the findings of a study of patients with small early lesions, which showed that, whereas mycobacteria were cultured from excised lesions 2 weeks after the start of antibiotic treatment, cultures were entirely negative at 4, 8 and 12 weeks (25).