एकाधिक BCC के साथ गोर्लिन सिंड्रोम में त्वचा के बेसल सेल कार्सिनोमा का उपचार

References

DOI: 10.1016/j.ejca.2023.113254

• Gorlin syndrome is a rare, autosomal dominant familial cancer syndrome with a high degree of penetrance and variable expression.
• Multiple BCCs in patients with Gorlin syndrome should be considered as laBCCs and treated accordingly.
• Depending on the number, size, location, and subtype of BCCs, treatment approaches used for sporadic BCC, besides radiotherapy, can be considered.
• The benefit of surgery should be weighed against the high risk of recurrent or newly developing BCCs and should be limited to solitary high-risk BCCs.
• Vice versa, small or superficial variants in low-risk areas outside the face may be managed by topical treatments and/or by careful watchful waiting during follow-up.
• Radiotherapy must be avoided because of the carcinogenic effect of X-rays resulting in the formation of new BCCs.