गंभीर मुँहासे वल्गेरिस का उपचार — और जब मानक मौखिक या सामयिक चिकित्सा कारगर न रही हो

References

DOI: 10.1016/j.jaad.2023.12.017

• For patients with severe acne or for patients who have failed standard treatment with oral or topical therapy, we recommend isotretinoin.
• We conditionally recommend daily dosing over intermittent dosing of isotretinoin based on low certainty evidence from 3 RCTs.
• We conditionally recommend either standard isotretinoin or lidose-isotretinoin based on high certainty evidence from 1 study.
• For persons with pregnancy potential, pregnancy prevention is mandatory with isotretinoin treatment.
• In a RCT of 925 patients comparing standard isotretinoin with lidose-isotretinoin, 81.0% of patients treated with standard isotretinoin experienced a 90% reduction in lesion count and 88.9% of patients treated with standard isotretinoin achieved treatment success after 20 weeks of treatment.