मुँहासे वल्गेरिस का प्रथम-पंक्ति सामयिक उपचार क्या है?

References

DOI: 10.1016/j.jaad.2023.12.017

• Topical therapies are the mainstay of acne treatment: they may be used for acne initial treatment and maintenance as monotherapy (except topical antibiotics) or used in combination with other topical or oral agents.
• When managing acne with topical therapies, multimodal therapy combining multiple mechanisms of actions is recommended as a good practice statement to optimize efficacy and to reduce the risk of antibiotic resistance.
• We recommend fixed-dose topical combinations of BP and topical retinoid, BP and topical antibiotic, and topical retinoid and topical antibiotic for acne treatment based on moderate certainty evidence.
• Notably, topical antibiotic monotherapy is not recommended due to concern for antibiotic resistance.
• Compared to vehicle at 12 weeks, a greater proportion of patients treated with topical retinoids achieved IGA success in 4 RCTs (risk ratio [RR], 1.57 [1.21, 2.04]).
• Compared to vehicle at 12 weeks, a greater proportion of patients treated with BP achieved IGA success in 3 RCTs (RR, 2.70 [1.10, 6.65]).