Herpes Zoster Not Responding to Acyclovir After 10–21 Days

This protocol addresses herpes zoster in patients whose infection has not responded to acyclovir treatment administered for 10 to 21 days — a presentation consistent with acyclovir resistance.

When a VZV infection fails to respond to an adequate acyclovir course of 10 to 21 days, acyclovir resistance should be considered the working diagnosis. This situation calls for a different therapeutic strategy than standard first-line treatment.

A specific alternative antiviral agent is indicated for acyclovir-resistant herpes zoster when standard therapy has been insufficient.

The complete protocol — including the agent, regimen details, and full clinical guidance — is available via the link below.