Patients with hereditary C1 inhibitor deficiency face a predictable risk of angioedema attacks when undergoing scheduled procedures or exposure to other known attack-inducing events. This clinical scenario calls for deliberate pre-procedural planning with short-term prophylaxis.
Hereditary C1 inhibitor deficiency in a patient scheduled for a medical, surgical, or dental procedure, or facing another known angioedema attack-inducing event, in whom short-term prophylaxis is indicated before the intervention.
First-line short-term prophylaxis involves a plasma-derived C1 inhibitor concentrate. The complete protocol — including the specific preparation, administration details, and how it relates to procedure timing — is available in the structured regimen below.
No angioedema near the site of intervention within 48 hours of the procedure.
DOI: 10.1111/all.15214