This protocol addresses the management of hepatocellular carcinoma (HCC) presenting as a localized tumor confined to the liver in a patient without underlying cirrhosis — a distinct clinical setting with specific treatment implications.
The tumor is localized and confined to the liver. Critically, there is an absence of cirrhosis — a key factor that shapes the therapeutic approach in this setting.
For patients in this scenario, a surgical intervention targeting the tumor is the recognized treatment of choice — representing the curative intent approach for this population. The full structured regimen, including eligibility criteria, procedural details, and clinical decision points, is available in the complete protocol.
Full algorithm and evidence-based details available below →DOI: 10.1097/HEP.0000000000000466
Surgical resection is the curative treatment of choice for patients with localized HCC in the absence of cirrhosis.
Surgical resection should be the treatment of choice for localized HCC in the absence of underlying cirrhosis (Level 2, Strong Recommendation).
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