Hemolytic-uremic syndrome
ICD-10 D59.3 · ICD-11 3A21.2

Treatment of HUS with Bloody Diarrhea in Shiga Toxin-Associated Disease

Shiga toxin-associated hemolytic-uremic syndrome (HUS) presenting with bloody diarrhea (dysentery) represents a specific clinical scenario. The combination of bloody stool and confirmed Shiga toxin exposure shapes the management approach for this patient population.

Clinical Scenario

This protocol covers Shiga toxin-associated HUS in patients who present with bloody diarrhea. Shiga toxin-associated gut infection is one of the chief causes of HUS and is confirmed by stool examination. The dysenteric presentation is a defining feature of this subgroup.

Treatment Approach — Partial Overview

In patients with this presentation who develop severe complications, a plasma-based therapeutic intervention may be an option in selected circumstances. The full protocol specifies the indications, clinical decision points, and complete approach.

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References
  1. Shiga toxin-associated gut infection is one of the chief causes of HUS and confirmed by stool examination.
  2. While we do not suggest the use of PEX in patients with Shiga toxin-associated HUS, therapy may be considered for patients with severe neurological or cardiac involvement.

DOI: 10.1007/s00467-019-04233-7

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