What is the treatment of hemolytic-uremic syndrome?
Hemolytic-uremic syndrome (HUS) requires prompt, coordinated management of acute kidney injury (AKI) alongside its haematologic complications. The clinical approach is protocol-driven, with specific considerations for fluid management, medication avoidance, renal support, and transfusion decisions.
Treatment approach
The protocol is built around standard supportive care for AKI — with particular attention to fluid and electrolyte balance and avoidance of agents that can worsen renal function — combined with criteria-guided decisions about transfusion support. Full eligibility criteria and the complete management sequence are in the structured protocol.
References
DOI: 10.1007/s00467-019-04233-7
- Standard recommendations should be followed for AKI with attention to fluid and electrolytes, avoiding radiocontrast and nephrotoxic agents, and timely institution of dialysis.
- Blood transfusion is recommended for patients with hemoglobin < 6 g/dl or hemodynamic instability.
- We suggest avoiding platelet transfusions unless count is < 10,000/μl, or to enable vascular catheter insertion.
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