This protocol applies to men presenting with gynecomastia in whom testosterone deficiency has been objectively confirmed. The established hormonal deficit is the defining feature of this population and is central to the management decision.
Proven testosterone deficiency is the prerequisite for treatment consideration in this setting. Clinical guidance is clear that intervention should be offered only to men in whom this deficiency has been confirmed — the diagnostic basis determines whether the approach is appropriate.
Management centres on testosterone substitution — directly addressing the confirmed hormonal deficit. The full protocol, including the structured clinical pathway and applicable parameters, is accessible via the link below.
DOI: 10.1111/andr.12636
We recommend that T treatment should be offered only to men with proven testosterone deficiency.
T treatment is effective only in patients with proven T deficiency, as in eugonadal men it may worsen GM due to enhanced aromatization to E2.
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