Treatment of Gynecomastia with Increased Aromatase Activity Identified by Elevated Estrogen Concentrations
In a subset of patients presenting with gynecomastia, the underlying driver is increased aromatase activity — a finding identifiable through elevated circulating estrogen concentrations. This biochemical picture defines a specific clinical scenario that informs which treatment approach is appropriate.
Clinical scenario
Increased aromatase activity per se, identified by the presence of elevated estrogen concentrations. This is a recognised but uncommon cause of gynecomastia and calls for a targeted therapeutic strategy.
Treatment approach
When increased aromatase activity is confirmed biochemically, a specific pharmacological class may be considered as an alternative to surgical treatment. The full eligibility criteria, decision logic, and complete regimen are available in the structured protocol.
References
In the rare cases of increased aromatase activity per se, which can be identified by the presence of elevated estrogen concentrations, treatment with AIs may be considered as an alternative to surgical treatment.
DOI: 10.1111/andr.12636
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