Granuloma inguinale (donovanosis) is a chronic bacterial infection causing progressive, destructive genital ulceration. The first-line protocol addresses active ulceration with the primary goal of achieving complete tissue healing.
The primary outcome of this protocol is complete healing of the genital ulcers, with formal reassessment at three weeks to confirm the therapeutic response.
The evidence-based first-line approach centres on macrolide antibiotic therapy. Treatment is continued until a defined healing endpoint is reached.