Glycogen storage disease type V can trigger episodes of muscle cramps, muscle contractures, or myalgia (muscle pain) when physical exertion places a demand on muscle that exceeds its capacity to produce energy quickly enough. Managing these episodes correctly is essential to prevent further muscle damage.

Clinical Scenario

Following intense aerobic or anaerobic activity — such as carrying a heavy object or bursts of sustained exertion — individuals with GSD-V may develop muscle cramps, contractures, or myalgia. These activity-triggered symptoms require immediate, targeted management that is distinct from long-term disease care.

Management Approach

The protocol focuses on immediate activity modification when symptoms arise; the full sequence of steps, including specific management considerations for contractures and an analgesic option for episodic cramps, is set out in the structured regimen below.

Treatment Goal

References

DOI: 10.1016/j.nmd.2021.10.006

Following intense aerobic and anaerobic activities (for example, carrying a heavy object or running for a bus), in which the metabolic demand on the muscle surpasses the ability of this tissue to produce energy fast enough, individuals may develop cramps, contractures, or worse, rhabdomyolysis.
To manage a cramp or contracture, cessation of the causal activity is recommended until pain resolves.
Unlike stretching of muscle cramps, stretching of a muscle in contracture may cause further muscle damage, and should be avoided.
To manage episodic occurrences of cramps, paracetamol (acetaminophen) may be taken after activity has ceased.

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Treatment of Glycogen Storage Disease Type V in Muscle Cramps, Contractures, or Pain Following Activity

Clinical Scenario

Management Approach

Treatment Goal

References