Glanzmann's thrombasthenia (GT) is a rare inherited platelet function disorder. When a patient with GT becomes pregnant, the bleeding risk at delivery creates a high-stakes clinical situation that demands coordinated advance planning.
Pregnant women with GT have a high rate of complications and are best managed in a specialised centre with a multidisciplinary team.
Delivery — whether vaginal or surgical — presents distinct haemostatic demands. The mode of delivery directly determines which haemostatic measures are indicated, and certain anaesthetic approaches carry specific restrictions in this population. Anticipating these requirements before labour begins is essential.
Management involves haemostatic support combined with antifibrinolytic therapy, with the specific combination differing by planned delivery route. The complete agent selection, decision criteria, and procedural constraints are detailed in the full protocol.
Pregnant women with GT have a high rate of complications and are best managed in a specialized center with a multidisciplinary team.
In general, regional anesthesia is contraindicated and support with rFVIIa and antifibrinolytics is given for vaginal deliveries with the option of adding platelet transfusion for cesarian sections.
DOI: 10.3324/haematol.2018.214239
View source ↗