When initial management of bleeding in Glanzmann's thrombasthenia does not achieve hemostasis, a structured escalation protocol is indicated. This page outlines the clinical scenario and the direction of next-line management.
The preceding management line uses rFVIIa — alone or with antifibrinolytics — for moderate to severe bleeding and minor surgical procedures. When hemostasis is not achieved with this approach, escalation to this protocol is warranted.
Severe or life-threatening bleeding, major surgical procedures, or significant bleeding that remains refractory to the measures above.
Management at this stage centres on platelet transfusion used in combination with other hemostatic agents. The specific agents, their combination, and the conditions under which each is applied are detailed in the full protocol.
Clinical goal: hemostasis achievedDOI: 10.3324/haematol.2018.214239