Treatment of Malignant Giant Cell Tumor of Bone — Primary or Secondary
This protocol covers the management of malignant giant cell tumor of bone (GCTB), which may arise as a primary malignancy or develop through secondary malignant transformation. The clinical approach differs depending on whether disease is localized or has spread beyond the primary site.
Clinical Scenario
Surgery is the mainstay of treatment for malignant GCTB. In patients with localized disease, wide resection is the recommended therapeutic option. The presence of distant metastases shifts the clinical calculus substantially and requires a distinct management strategy.
Treatment Approach — Partial Overview
For malignant GCTB with distant metastases, management moves toward a palliative intent. A combination of modalities is recommended in this setting. The complete regimen — including the specific interventions, their sequence, and selection criteria — is detailed in the full structured protocol.
References
- Surgery is the mainstay treatment for malignant GCTB.
- For patients with localized malignant GCTB, wide resection is the recommended therapeutic option.
- Palliative chemotherapy, radiation therapy, and surgery are recommended for the treatment of malignant GCTB with distant metastases.
DOI: 10.3390/curroncol31040157
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