Treatment of Giant Cell Tumor of Bone with Pulmonary (Lung) Metastasis

Giant cell tumor of bone occasionally spreads to the lungs. When pulmonary metastases are confirmed, the clinical question becomes how to manage these lesions and prevent further progression.

Clinical Scenario

This protocol applies to patients with giant cell tumor of bone who have developed pulmonary metastases — a complication that occurs in 1–9% of cases. The therapeutic goal is halted progression of lung metastases, achieving stable disease.

Treatment Approach

For enlarging lung metastases, a targeted therapy is used as the primary intervention. The complete regimen, full selection criteria, and monitoring details are available in the structured protocol below.

Instant Access to Structured Evidence-Based Regimens

References

Pulmonary metastasis occurs in 1–9% of cases.

For those that enlarge, denosumab is administered every 3 months.

Denosumab is able to halt the progression of lung metastases.

DOI: 10.3390/curroncol31040157

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