Treatment of Giant Cell Tumor of Bone of the Spine — Enneking Stage 2

This protocol addresses the management of giant cell tumor of bone (GCTB) arising in the spine when the tumor is classified as Enneking stage 2: symptomatic and intracompartmental (active).

Clinical scenario

The majority of GCTBs are symptomatic and intracompartmental (active; stage 2) or symptomatic and extracompartmental (aggressive; stage 3). This protocol applies to stage 2 spinal lesions — those that are symptomatic yet remain confined within their compartment.

Surgical approach — overview

For Enneking stage 2 spinal lesions, the recommended surgical strategy involves a subtotal resection of the tumor. The full procedural detail, eligibility criteria, and any additional considerations are available in the complete protocol.

Full regimen details, technique guidance, and structured evidence are accessible via the link below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.3390/curroncol31040157

The majority of GCTBs are symptomatic and intracompartmental (active; S2) or symptomatic and extracompartmental (aggressive; S3).

For Enneking stage 2 tumors, curettage is recommended.

Subtotal resection (i.e., curettage) and piecemeal total spondylectomy or total en bloc spondylectomy are suitable for the treatment of S2 and S3 lesions, respectively.

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