Treatment of Active Pemphigoid Gestationis in the Post-Partum or Post-Abortion Period

Clinical Scenario

This protocol covers pemphigoid gestationis that remains active following delivery or pregnancy loss — a presentation that occurs outside of pregnancy itself, in the post-partum or post-abortion period, and that calls for a specific therapeutic strategy distinct from in-pregnancy management.

Treatment Approach

First-line management in this period centres on immunosuppressant or immunomodulating therapy. One agent used in this setting requires specific infant monitoring when the mother is breastfeeding.

The complete structured regimen — agent selection, sequencing, clinical considerations, and full evidence base — is available in the full protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.3389/fmed.2020.604945

In the post-partum/post-abortion period, we suggest as first step treatment immunosuppressant/immunomodulating agents, including dapsone and azathioprine, leaving as second choices IVIg and rituximab due to pharmacoeconomic reasons.

Dapsone (during lactation monitor infant G6PDH deficiency and hemolysis)

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