Treatment of Pemphigoid Gestationis with Active Disease in the Post-Partum Period

Pemphigoid gestationis (PG) may persist or flare after delivery or following pregnancy loss. When active disease is present in the post-partum or post-abortion period, management differs from in-pregnancy care and a defined first-line approach applies.

Clinical scenario

Pemphigoid gestationis with active disease in the post-partum or post-abortion period — disease that has not remitted after the end of pregnancy.

Treatment approach

The evidence-based first-line approach for this scenario centres on systemic corticosteroid therapy; the full protocol specifies the complete regimen and all decision points.

Dosing, sequencing, and adjunctive options are detailed in the structured protocol below →

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.3389/fmed.2020.604945

In the post-partum/post-abortion period, we suggest as first step treatment immunosuppressant/immunomodulating agents, including dapsone and azathioprine, leaving as second choices IVIg and rituximab due to pharmacoeconomic reasons.
In refractory disease, systemic corticosteroids may be attempted.
SCs (prednisone 0.5 mg/kg/day) ± TCs and/or antihistamines

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