Gestational Pemphigoid with Active Disease During Pregnancy

This protocol addresses pemphigoid gestationis presenting with active disease during pregnancy — distinct from post-partum or post-abortion presentations — where clinical management must account for the concurrent pregnancy.

Clinical scenario: Pemphigoid gestationis with active disease during pregnancy (not in the post-partum or post-abortion period).

Treatment approach (partial)

A specific agent is considered in this setting when a key maternal enzymatic deficiency has been excluded. The full protocol specifies the agent, its conditions for use, and the complete decision pathway.

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References

DOI: 10.3389/fmed.2020.604945

In case of failure/contraindication/side effects of systemic corticosteroids, we suggest to consider during pregnancy intravenous immunoglobulin therapy and, as second step, conventional immunosuppressants/immunomodulating agents such as dapsone or azathioprine, which are the last choice, which can be used safely during pregnancy as inferred from many studies involving patients with other diseases treated with these agents.

Dapsone (if absence of maternal G6PDH deficiency)

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