Treatment of Gestational Pemphigoid with Active Disease During Pregnancy

This protocol addresses pemphigoid gestationis presenting with active disease during pregnancy — specifically in the antenatal period, not the post-partum or post-abortion setting.

Clinical Scenario

Active pemphigoid gestationis occurring during pregnancy. The protocol is specific to this antenatal window and does not apply to post-partum or post-abortion presentations.

Treatment Approach (Partial Overview)

The structured protocol includes intravenous immunoglobulin therapy — considered in relation to systemic corticosteroids — as part of a defined, step-by-step management strategy. The full sequencing, criteria for escalation, and complete regimen details are in the protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.3389/fmed.2020.604945

In case of failure/contraindication/side effects of systemic corticosteroids, we suggest to consider during pregnancy intravenous immunoglobulin therapy and, as second step, conventional immunosuppressants/immunomodulating agents such as dapsone or azathioprine, which are the last choice, which can be used safely during pregnancy as inferred from many studies involving patients with other diseases treated with these agents.

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