Treatment of Gestational Pemphigoid with Active Disease During Pregnancy
This protocol covers pemphigoid gestationis presenting with active disease during pregnancy — cases that are not in the post-partum or post-abortion period.
Clinical Scenario
Active pemphigoid gestationis during pregnancy requiring therapeutic management, with treatment choices informed by the safety considerations specific to the pregnant patient.
Treatment Approach
First-line management centres on systemic corticosteroid therapy. Topical corticosteroids and/or antihistamines may be added as adjuncts. The complete regimen — including agent selection, dosing, and clinical guidance — is available in the full protocol.
References
DOI: 10.3389/fmed.2020.604945
- In refractory disease, systemic corticosteroids may be attempted.
- SCs (prednisone 0.5 mg/kg/day) ± TCs and/or antihistamines
- In case of failure/contraindication/side effects of systemic corticosteroids, we suggest to consider during pregnancy intravenous immunoglobulin therapy and, as second step, conventional immunosuppressants/immunomodulating agents such as dapsone or azathioprine, which are the last choice, which can be used safely during pregnancy as inferred from many studies involving patients with other diseases treated with these agents.
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