Treatment of Recurrent Genital Herpes in People Living with HIV

Recurrent genital herpes presents a distinct clinical challenge in people living with HIV, where both the frequency and severity of outbreaks are significantly greater than in the general population.

Clinical Situation

Both clinical and subclinical reactivations of genital herpes are more frequent in people living with HIV and may lead to persistent and progressive anogenital mucocutaneous lesions, especially with CD4 cell counts below 50 per mm³.

Treatment Approach

Antiviral therapy is used to manage recurrent episodes in this population. The specific agent and full regimen details are available in the complete structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1111/jdv.20450

Both clinical and subclinical reactivations of genital herpes are more frequent in people living with HIV and may lead to persistent and progressive anogenital mucocutaneous lesions, especially with CD4 cell counts <50 per mm3.
If control is still not achieved then famciclovir 500 mg orally twice a day can be tried (1, B).

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