GERD in Pregnancy When Lifestyle Modifications Have Not Relieved Heartburn
Gastroesophageal reflux disease is common during pregnancy. When an initial course of lifestyle modifications fails to control symptoms, a defined pharmacological next step is available.
Clinical Setting
This protocol applies to pregnant patients with gastroesophageal reflux disease. Approximately two-thirds of pregnant women experience heartburn, which can begin in any trimester.
Prior Treatment — Targets Not Met
Previous therapy: Lifestyle modifications.
Goals not achieved: Relief of heartburn and regurgitation.
This protocol defines the next course of action when lifestyle modifications alone have been insufficient.
Next-Line Approach (Partial Overview)
The protocol moves to specific neutralizing and protective first-line therapeutic agents. The complete agent selection and clinical approach are detailed in the full protocol.
References
- Approximately two-thirds of pregnant women experience heartburn, which can begin in any trimester.
- When lifestyle modifications fail, antacids (aluminum-, calcium-, or magnesium-containing), alginates, and sucralfate are the first-line therapeutic agents.
- A small randomized controlled trial found that sucralfate was superior to dietary and lifestyle modifications for relieving heartburn and regurgitation in pregnant women.
DOI: 10.14309/ajg.0000000000001538
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