Gastroesophageal reflux disease
ICD-10 K21 · ICD-11 DA22

GERD with Extraesophageal Manifestations (Chronic Cough, Hoarseness, Laryngitis) and Heartburn

Clinical scenario

This protocol addresses patients with gastroesophageal reflux disease who present with extraesophageal manifestations — such as chronic cough, hoarseness, or laryngitis — together with typical GERD symptoms of heartburn and/or regurgitation.

Conditions present
Chronic cough Hoarseness Laryngitis Heartburn Regurgitation

The co-occurrence of extraesophageal complaints alongside classic reflux symptoms — particularly heartburn — defines this specific patient population and informs the recommended initial management pathway.

Treatment approach (partial)

An initial empirical trial of PPI (proton pump inhibitor) therapy is the recommended first step — the specific regimen, dosing schedule, and duration are detailed in the full structured protocol.

Treatment goal

Improvement of the extraesophageal symptoms.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.14309/ajg.0000000000001538

For patients who have both extraesophageal and typical GERD symptoms we suggest considering a trial of twice-daily PPI therapy for 8 to 12 weeks prior to additional testing.

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