Treatment of Functional Dyspepsia in Absence of Helicobacter pylori Infection
This protocol applies to patients with functional dyspepsia (FD) in whom Helicobacter pylori infection has been excluded — a clinically important subgroup with its own evidence-based management pathway.
Clinical Scenario
Functional dyspepsia presenting in a patient who tests negative for H. pylori defines this specific subgroup. The absence of infection is a key determinant of the management pathway and shapes the sequence of interventions considered.
Treatment Approach
For this population, the protocol includes referral for a gut-brain behavioural therapy. The particular type of intervention and how it is applied are specified in the full structured regimen.
References
DOI: 10.1136/gutjnl-2022-327737
- We recommend that patients without H. pylori infection are offered empirical acid suppression therapy (recommendation: strong; quality of evidence: high).
- CBT and metacognitive therapy may be an efficacious treatment for global symptoms in FD (recommendation: weak, quality of evidence: very low).
- Hypnotherapy may be an efficacious treatment for global symptoms in FD (recommendation: weak, quality of evidence: very low).
- Stress management approaches may be an efficacious treatment for global symptoms in FD (recommendation: weak, quality of evidence: very low).
- Interpersonal psychodynamic informed psychotherapy may be an efficacious treatment for global symptoms in FD (recommendation: weak, quality of evidence: very low).
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