Treatment of Functional Dyspepsia in the Absence of Helicobacter pylori Infection
Clinical Scenario
This protocol applies to patients with a diagnosis of functional dyspepsia who have tested negative for Helicobacter pylori infection. Because H. pylori eradication is not a treatment option in this population, empirical therapy is recommended as the first step.
First-Line Approach (Partial Overview)
Current evidence supports empirical acid suppression therapy as the initial management strategy for these patients. The protocol specifies which agent class to use and guides selection of the appropriate dose level — the full regimen and decision algorithm are available through the link below.
Full protocol details, dosing guidance, and sequencing available via the link below.
References
DOI: 10.1136/gutjnl-2022-327737
- We recommend that patients without H. pylori infection are offered empirical acid suppression therapy (recommendation: strong; quality of evidence: high).
- However, there is evidence that acid suppression therapy with H2RAs or PPIs is beneficial.
- PPIs are an efficacious treatment for FD. There does not appear to be a dose response, so the lowest dose that controls symptoms should be used.
- Histamine-2-receptor antagonists may be an efficacious treatment for FD.
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