This protocol addresses adults with confirmed grade 3 or 4 deep extremity frostbite who are 25–72 hours out from rewarming and who are not currently receiving active treatment for systemic hypothermia.
Clinical evaluation confirms severe frostbite with cyanosis at or proximal to the metatarsophalangeal joint, consistent with grade 3–4 injury. The patient falls within the critical 25–72-hour post-rewarming window, and acute systemic hypothermia is not being actively managed.
The protocol initiates iloprost delivered as a continuous intravenous infusion in a monitored inpatient setting with continuous telemetry — the complete dosing algorithm, titration schedule, and duration are available in the full structured regimen.