Les composés 5-nitroimidazoles constituent le traitement standard de la trichomonase urogénitale. Lorsqu'un patient présente une hypersensibilité confirmée à cette classe médicamenteuse, une approche thérapeutique entièrement différente est nécessaire.
Ce protocole est indiqué pour les patients atteints de trichomonase urogénitale présentant une hypersensibilité documentée aux médicaments 5-nitroimidazoles, rendant les agents conventionnels de première intention contre-indiqués.
DOI: 10.1128/cmr.00109-16
Although the 5-nitroimidazole compounds are the most effective drugs for treating T. vaginalis infection, disulfiram and nithiamide (Fig. 2c and d) might represent alternatives for treating patients with hypersensitivity to 5-nitroimidazole drugs.
In a study conducted on nine patients infected with T. vaginalis, among whom four patients had strains that were metronidazole resistant and five patients were allergic to metronidazole, treatment with paromomycin cream (250 mg per 4-g applicator nightly) was achieved for 2 weeks, and six of nine women were cured.
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