Treatment of Early-Stage Follicular Lymphoma After Localised Excision When Radiotherapy Is a Concern

In patients with stage I-II (limited/early-stage) follicular lymphoma who have already undergone localised excision, the question of further treatment — specifically whether involved-site radiotherapy is appropriate — requires careful consideration when either the clinician or the patient has concerns about radiotherapy to the affected site.

This protocol applies to patients with limited-stage follicular lymphoma who have had localised surgical excision of disease and where proceeding with involved-site radiotherapy is not straightforward — due to anatomical site, potential toxicity, or patient preference. The decision about whether to irradiate or pursue an alternative strategy is a recognised point of clinical judgement in this population.

In this setting, the evidence supports an observation-based strategy as an alternative to radiotherapy — the full structured regimen, including criteria and follow-up framework, is in the complete protocol…