For patients with focal epilepsy whose seizures remain inadequately controlled after first-line add-on antiseizure treatment has been tried, a structured second-line add-on approach is indicated.
This protocol addresses focal epilepsy in patients who have already received first-line add-on antiseizure therapy and in whom that treatment has proved unsuccessful — requiring escalation to a defined second-line add-on strategy.
The protocol specifies a set of second-line add-on antiseizure medication options to consider, along with a defined next step if the initial selection from that group also fails. Full selection guidance and sequencing are available in the protocol.
If first-line add-on treatments tried are unsuccessful in people with focal seizures, consider 1 of the following second-line add-on treatment options.
If the first choice is unsuccessful, consider the other second-line add-on.
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