This protocol addresses patients with focal epilepsy whose focal seizures have not been adequately controlled on initial antiseizure monotherapy, and who require a structured approach to selecting the next treatment step.
When focal seizure control is not achieved with monotherapy, guidelines support the addition of a first-line add-on antiseizure medication chosen from a defined set of options. At least one of the recognised agents carries specific prescribing restrictions for women and girls of childbearing potential.
If the initial add-on choice does not achieve the desired response, a switch to another option from the same first-line group is recommended.